“生物信息学”学术报告
时间：2012年10月23日（周二）上午9:30
地点：逸夫科技馆3楼生物电子学国家重点实验室会议室
时间：2012年10月23日（周二）上午9:30
地点：逸夫科技馆3楼生物电子学国家重点实验室会议室
报告人：周童博士
报告人单位：Institute for Personalized Respiratory Medicine, Department of Medicine, The University of Illinois at Chicago
报告题目： Sound of silence: non-neutral tale on mRNA secondary structure
[Abstract]
Because of the structure of the genetic code, synonymous mutations in genes will not obviously affect the resultant protein and are hence considered “silent”. If they don't affect the protein, silent mutations cannot cause genetic disease. However, silent mutations are now acknowledged to be able to cause changes in protein expression, conformation and function. The recent increase in knowledge about the relationship between mRNA secondary structure and silent mutations has revealed a substantial contribution of such mutations to human disease risk and other complex traits. Here we review current understanding of the extent to which silent mutations influence mRNA secondary structure, the various molecular mechanisms that underlie these effects and the implications for future research and biomedical applications. We also indicate that even non-synonymous mutations may cause human diseases by altering mRNA secondary structure instead of changing protein function.
[Abstract]
Because of the structure of the genetic code, synonymous mutations in genes will not obviously affect the resultant protein and are hence considered “silent”. If they don't affect the protein, silent mutations cannot cause genetic disease. However, silent mutations are now acknowledged to be able to cause changes in protein expression, conformation and function. The recent increase in knowledge about the relationship between mRNA secondary structure and silent mutations has revealed a substantial contribution of such mutations to human disease risk and other complex traits. Here we review current understanding of the extent to which silent mutations influence mRNA secondary structure, the various molecular mechanisms that underlie these effects and the implications for future research and biomedical applications. We also indicate that even non-synonymous mutations may cause human diseases by altering mRNA secondary structure instead of changing protein function.
周童博士简介（附件是CV）：
Dr. Zhou completed his B.S. in Biomedical Engineering at the Southeast
University in 2000, and received his PhD from the Southeast University in
2006. He completed postdoctoral training in computational biology at the
University of Texas at Austin (2006 -2010).
Dr. Zhou completed his B.S. in Biomedical Engineering at the Southeast
University in 2000, and received his PhD from the Southeast University in
2006. He completed postdoctoral training in computational biology at the
University of Texas at Austin (2006 -2010).
Dr. Zhou began his academic career as a Research Assistant Professor of
Medicine at the University of Illinois Medical Center (2010 -- present)
where he focus on molecular evolution and clinical bioinformatics
Medicine at the University of Illinois Medical Center (2010 -- present)
where he focus on molecular evolution and clinical bioinformatics